Buy Detrol Online

What is Detrol?

Detrol (tolterodine) reduces spasms of the bladder muscles.

Detrol is used to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence.

Detrol may also be used for other purposes not listed in this medication guide.

Important information about Detrol

Do not take Detrol if you are allergic to tolterodine or or fesoterodine (Toviaz), if you have untreated or uncontrolled narrow-angle glaucoma, or if you have a blockage of the urinary tract, stomach, or intestines.

Before you take Detrol, tell your doctor if you have kidney or liver disease, glaucoma, myasthenia gravis, or a personal or family history of "Long QT syndrome."

Do not crush, chew, break, or open a Detrol LA controlled-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Detrol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase some of the side effects of Detrol.

There are many other drugs that can interact with Detrol. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Before taking Detrol

You should not use Detrol if your are allergic to tolterodine or fesoterodine (Toviaz), or if you have:

  • a blockage of the urinary tract (difficulty urinating);

  • a blockage in your stomach or intestines; or

  • untreated or uncontrolled narrow-angle glaucoma.

To make sure you can safely take Detrol, tell your doctor if you have any of these other conditions:

  • liver disease;
  • kidney disease;
  • myasthenia gravis;

  • glaucoma; or

  • a personal or family history of Long QT syndrome.

FDA pregnancy category C. It is not known whether Detrol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether tolterodine passes into breast milk or if it could harm a nursing baby. Do not use Detrol without telling your doctor if you are breast-feeding a baby.

How should I take Detrol?

Take Detrol exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take Detrol with water. Do not crush, chew, break, or open a controlled-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Store Detrol at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, blurred vision, and fast heartbeat.

What should I avoid while taking Detrol?

Detrol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase some of the side effects of Detrol.

Detrol side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Detrol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Detrol and call your doctor at once if you have any of these serious side effects:

  • chest pain, fast or uneven heart rate;

  • confusion, hallucinations;

  • urinating less than usual or not at all; or

  • painful or difficult urination.

Less serious Detrol side effects may include:

  • dry mouth, dry eyes;

  • blurred vision;

  • dizziness, drowsiness;

  • constipation or diarrhea;

  • stomach pain or upset;

  • joint pain; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Detrol?

Before taking Detrol, tell your doctor about all other medicines you use, especially:

  • arsenic trioxide (Trisenox);

  • chloroquine (Arelan) or halofantrine (Halfan);

  • cyclosporine (Gengraf, Neoral, Sandimmune);

  • droperidol (Inapsine);

  • narcotic medication such as levomethadyl (Orlaam) or methadone (Dolophine, Methadose);

  • pentamidine (NebuPent, Pentam);

  • vinblastine (Velban);

  • antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), pentamidine (NebuPent, Pentam), or telithromycin (Ketek);

  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil) pimozide (Orap), or thioridazine (Mellaril); or

  • heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), procainamide (Procan, Pronestyl), quinidine (Quin-G), or sotalol (Betapace).

This list is not complete and there are many other drugs that can interact with Detrol. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

For the Consumer

Applies to tolterodine: oral capsule extended release, oral tablet

Along with its needed effects, tolterodine (the active ingredient contained in Detrol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tolterodine:

More common
  • Abnormal vision, including difficulty with adjusting to distances
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
Less common
  • Chest pain
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • shivering
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • sweating
  • tightness of the chest or wheezing
  • trouble with sleeping
  • vomiting
Incidence not known
  • Being forgetful
  • bloating or swelling of the face, arms, hands, ankles, lower legs, or feet
  • confusion about identity, place, and time
  • difficulty with swallowing
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • mood or mental changes
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • seeing, hearing, or feeling things that are not there
  • skin rash
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Some side effects of tolterodine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • constipation
  • drowsiness
  • dry eyes
  • dry mouth
  • upset stomach
Less common
  • Acid or sour stomach
  • belching
  • blurred vision
  • difficulty with moving
  • dizziness or lightheadedness
  • dry skin
  • fear or nervousness
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • stomach discomfort
  • weight gain

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Applies to tolterodine: oral capsule extended release, oral tablet

General

General side effects reported during postmarketing experience have included hallucinations. Most of the side effects of tolterodine (the active ingredient contained in Detrol) are extensions of its pharmacologic activity and are anticholinergic in nature. In clinical trials, 8% of patients discontinued treatment due to adverse events. Among the most common complaints leading to discontinuation was headache, which occurred in 11% of patients.

Gastrointestinal

Gastrointestinal side effects reported the most frequently have included dry mouth (19.7% to 39.5%). Dyspepsia, constipation, abdominal pain, and flatulence have been reported in 1% to 10% of patients. Diarrhea (1.8%), nausea (1.2%), and gastroesophageal reflux (1%) have been reported. Decreased motility and GI hemorrhage have been reported during postmarketing experience.

Most reports of dry mouth were mild to moderate in intensity. Severe dry mouth was reported during therapy with tolterodine by 1% to 5% of patients in several large, placebo controlled studies.

Ocular

Ocular side effects have included abnormal or blurred vision (4.7%) and xerophthalmia (3.8%).

Nervous system

Reports of aggravation of symptoms of dementia (e.g., confusion, disorientation, and delusion) have been reported after tolterodine (the active ingredient contained in Detrol) therapy was initiated in patients taking cholinesterase inhibitors for the treatment of dementia.

A 73-year-old female presented with a two-year history of decreased short-term memory and vivid hallucinations of deceased relatives that occurred only during nighttime sleep; she awoke regularly to converse with these relatives. The symptoms began several weeks after taking tolterodine (2 mg twice daily) for urinary incontinence. These hallucinations did not distress the patient and resolved after three months of donepezil treatment. Her memory impairment improved after tolterodine was discontinued for several months. It recurred after tolterodine therapy was restarted.

Nervous system side effects including headache, vertigo or dizziness, and fatigue have been reported in 1% to 10% of patients. Somnolence (0.4% to 10%), asthenia (3.6%), insomnia (0.4% to 1.6%), nervousness (1%), confusion (less than 1%), and hallucinations (less than 1%) have been reported. Syncope, convulsions, disorientation, memory impairment, and aggravation of symptoms of dementia (e.g., confusion, disorientation, and delusion) have been reported during postmarketing experience.

Genitourinary

Genitourinary side effects including dysuria (1% to 10%), urinary tract infection (0.4% to 9%), urinary retention (less than 1% to 1.7%), and impaired urination (0.4%) have been reported.

Cardiovascular

Cardiovascular side effects have infrequently included hypertension or minor increases in heart rate. Peripheral edema has been reported in 1% of patients. Tachycardia, peripheral edema, chest pain, ventricular arrhythmia, atrial fibrillation, cardiac failure, palpitations, bradycardia, collapse, and transient ischemic attacks have been reported during postmarking experience.

Hypersensitivity

Hypersensitivity side effects including allergic reactions have been reported in less than 1% of patients. Anaphylactoid reactions have been reported during postmarketing experience.

Hepatic

Hepatic side effects have rarely included acute mixed liver injury. Hepatic dysfunction has also been reported during postmarketing experience.

Dermatologic

Dermatologic side effects including flushed skin have been reported in less than 1% of patients.

Respiratory

Respiratory side effects including bronchitis and sinusitis have been reported in 1% to 10% of patients. Cough (4% to 7%), rhinitis (4% to 7%), sore throat (4% to 7%), respiratory infection (4% to 6%), and influenza (0.4% to 1%) have been reported.

Metabolic

Metabolic side effects including weight gain have been reported in 1% to 10% of patients.

Psychiatric

Psychiatric side effects including depression have been reported during postmarketing experience.

Renal

Renal side effects including renal dysfunction have been reported during postmarketing experience.

Other

Other side effects including pyrexia have been reported in 4% of patients.